SYNTHESIS AND CHARACTERIZATION OF 1, 3, 4-OXADIAZOLE AND 1,3,4- THIADIAZOLE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1, 3, 4-oxadiazole and 1,3,4- thiadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Literature is flooded with reports of a variety of biological activities of 2, 5-Disubstituted-1,3,4- oxadiazoles and 1,3,4- thiadiazole. The search for better anticonvulsant drug and the importance of 2,5- disubstituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole for their potential anticonvulsant activity by autodock software.
Authors and Affiliations
Ramanji Naik
Keywords
Related Articles
- EP ID EP33062
- DOI -
- Views 287
- Downloads 0
The study of antihyperglycaemic activity of aqueous extract of root of Cleome chelidonii herb in rats
The work was aimed to explore the hypoglycaemic and antihyperglycaemic activity of aqueous extract of root of Cleome chelidonii herb. The extract was evaluated for its specific physical and chemical characteristics in...
Determination of force degradation and solution stability studies of (bortezomib) proteasome inhibitor by HPLC method
A forced degradation study is an essential step in the design of a regulatory compliant stability program for both drug substances and products, and formalized as a regulatory requirement in ICH Guideline Q1A in 1993....
Development and validation of new RP-HPLC method for simultaneous estimation of drug Duloxetine and Mecobalamin in tablet dosage form
A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Duloxetine and Mecobalamin was developed and validated according to ICH guidelines. The quantificatio...
Formulation and evaluation of transdermal patches of Irbesartan
The purpose of the research was to develop matrix type transdermal therapeutic system containing irbesartan with different ratios of hydrophilic and hydrophobic polymeric concentration by the solvent evaporation techni...
A simple validated UV spectrophotometric method for the estimation of Vilazodone hydrochloride in pure and marketed formulation
A simple, accurate, rapid and sensitive UV Spectrophotometric method has been developed and validated for the estimation of Vilazodone Hydrochloride (VLH) in bulk as well as in marketed formulation. Vilazodone Hydrochl...