Hypoglycemic and antihyperglycemic activities of Bauhinia thonningii (caesalpiniaceae) fruit in rat wistar
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 1
Abstract
Diabetes is a metabolic disease characterized by chronic hyperglycemia resulting from a defect in the secretion of insulin and / or the action of this hormone. The therapeutic management of this pathology in most developing countries is costly given the low purchasing power of the populations. The traditional African pharmacopoeia offers an alternative to synthetic antidiabetics. The objective of this study is to demonstrate the hypoglycaemic and anti-hyperglycemic properties of Bauhinia thonningii (Caesalpiniaceae) fruits in rats. The aqueous extract of the fruits of this plant was administered orally to different batches of normoglycemic rats and then to hyperglycemic rats at doses of 25, 50, 100 and 150 mg / kg body weight (bw). The results of this study showed that the fruits of Bauhinia thonningi possess hypoglycaemic (p = 0.0356) and anti-hyperglycemic (p <0.0001) properties.
Authors and Affiliations
Bédou Kouassi Denis, Baba O Zeine Mohamed Anouar Sadat, Konkon Ndri Gilles, Edjeme-Aké angèle, Djaman Allico Joseph, N’guessan Jean-David
Keywords
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