NEPHROPROTECTIVE ACTIVITY OF EHANOLIC EXTRACT OF ELEPHANTOPHUS SCABER LEAVES ON ALBIO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
In traditional medicine, different parts of Elephantopus scaber Linn are highly valued for the treatment of array of human diseases including cardiotonic, diuretic, hepatoprotective, antimicrobial, anti-inflammatory activity etc. In the present study, single oral dose (200-600 mg/kg/day for 7 days) of ethanolic leaf extract of Elephantopus scaber Linn. Leaves were studied for its nephroprotective effect on albino rats. In the study of gentamicin induced nephrotoxicity, thirty adult male Wistar rats were evenly divided into five groups of six animals each. The treated groups, which were pretreated with the dose of 200, 400 and 600 mg/kg body weight per day of leaf extract respectively one hour before each dose of the nephrotoxicants for seven days and compared with control group. On 7th day, the blood samples of all the groups were taken for biochemical examination on different parameters i.e. serum levels of urea, protein and creatinine, as well as quantitative ionic estimation of some ions like sodium, potassium, chloride, bicarbonate etc. Histological analysis of rat kidneys and body weight as well as kidney wt were also observed. In the study of gentamicin induced nephrotoxicity on rats, the dose of tested extract at 200–600 mg/kg/day significantly (p < 0.01) decreases the levels of serum creatinine, total protein and serum urea but shows slightly increase on the electrolyte levels in dose dependent manner. The nephroprotective effect of Elephantopus scaber could be due to flavonoid content and the inherent antioxidant moieties in the extract. The ethanolic extract of Eelphantopus scaber leaves could constitute a lead to discovery of a novel drug for the treatment of drug-induced Nephrotoxicity.
Authors and Affiliations
Himanshu Sahoo , Sudhanshu Swain , Subhangankar Nandy , Rakesh Sagar , Amrita Bhaiji
Keywords
Related Articles
- EP ID EP86835
- DOI -
- Views 151
- Downloads 0
PEPTIC ULCER: A REVIEW ON ETIOLOGY AND PATHOGENESIS
A peptic ulcer is a sore on the lining of the stomach or duodenum. The two most common types of peptic ulcer are called “gastric ulcers” and “duodenal ulcers”. Peptic ulcers are found to be due to an imbalance between ag...
FORMULATION AND EVALUATION OF CARVEDILOL TRANSDERMAL PATCHES
The present study was carried out to develop and evaluate matrix-type transdermal formulations containing carvedilol with different ratios of hydrophilic (HPMC) and hydrophobic polymeric (Eudragit RS100) combinations pla...
EVALUATION OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF DALBERGIA SISSOO LEAVES IN EXPERIMENTAL ANIMALS
Gastric ulcer is one of the major health problems in developing countries. Furthermore, high cost and of adverse effects are seen with the long term use of allopathic drugs in treatment of ulcer which are diminished by t...
ANTIHYPERLIPIDEMIC ACTIVITY OF DIVYA METHIPACHAK AGAINST TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS
The present study was designed to evaluate the anti-hyperlipidemic activity of Divya Methipachak a polyherbal formulation against triton induced hyperlipidemia in rats. Hyperlipidemia was induced by Triton X-100 (100 mg/...
SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONE DERIVATIVES FOR ANTIDIABETIC ACTIVITY
The aim of study was to synthesize a new series of thiazolidinedione’s. Thiazolidinedione’s or glitziness forms a significant class of drugs which exhibit biological activities ranging from antidiabetic, anti-inflammator...