Post-Therapy Leukocytosis Events After Intravenous Aminophylline Compared to the Nebulized Salbutamol in Asthma Exacerbations Patients
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2016, Vol 5, Issue 3
Abstract
Salbutamol known as the first-line therapy for asthma exacerbations symptoms relieving. Aminophylline are now no longer used because of its narrow therapeutic range of drugs and frequently provoking adverse drug reaction (ADR). Both of these therapies can lead to ADR-related leukocytes level increasing that interfere the concurrent therapies. This study was aimed to compare the state of leukocytosis after therapy with salbutamol nebulizer therapy as the first-line therapy with intravenous aminophylline for the treatment of asthma exacerbations. Quasi experimental method was used in this study, with blood leukocytes profile measure before and after the intervention body temperature measurement as data supplement. This research was conducted in January 2014–June 2015 at several hospitals in Surabaya, Indonesia. The incidence of ADRs associated leukocytes in aminophylline group (n=2) with a value scale naranjo by 6 points, most likely ADR. Significant difference found only in leukocyte level in two patient. More biomarkers profiles should be monitored assording to concurrent therapies for asthma exacerbation.
Authors and Affiliations
Amelia Lorensia, Zullies Ikawati, Tri M. Andayani, Daniel Maranatha, Mariana Wahjudi
Keywords
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- EP ID EP367859
- DOI 10.15416/ijcp.2016.5.3.149
- Views 110
- Downloads 0
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