Formulation & evaluation of aripiprazole solid lipid nanoparticles for brain targeting
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 5
Abstract
The objective of this research work was to formulate Aripiprazole solid lipid nanoparticles for brain targeting by surpassing the Blood brain barrier (BBB) and increasing the retention time in the brain for better therapy. The peaks obtained in the physical mixture were mostly identical with the peaks of the pure sample indicating their compatibility. The Solid lipid nanoparticles containing Aripiprazole was formulated by High speed homogenization technique using Ultra Turrax T25, IKA high speed homogenizer. When subjected to evaluation, it was observed that maximum entrapment efficiency was achieved with formulations F8 and F11. In-vitro diffusion studies of all the formulations followed firstorder kinetics and ascertained Peppas mechanism. Based on the release profile and the entrapment efficiency, the formulations F8 & F11 were found to be the optimized .SEM analysis revealed that the particles were spherical in shape. The particle size range of the solid lipid nanoparticle formulations F8 and F11 were found to be 120nm to 400nm and 150nm to 520nm with the average particle size of 202.6nm and 263.9nm respectively. The zeta potential of the optimized formulations (F8 and F11) were found to be - 28.9 mV & -33.1mV indicating the higher negative surface charge claiming to possess good stability. From the above results, it can be concluded that Aripiprazole Solid lipid nanoparticles could act as better formulation for the effective management of psychotic disorders.
Authors and Affiliations
Sabbavarapu Mary Samyuktha, Nuditelli Mounica, Ravipati Sireesha, Karanki Pavani, Kishore Babu M
Keywords
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